Clinical Nutrition

Statin Use and 25-Hydroxyvitamin D Blood Level Response to Vitamin D Treatment of Older Adults.

Bischoff-Ferrari HA1,2, Fischer K1,2, Orav EJ3, Dawson-Hughes B4, Meyer U1,2, Chocano-Bedoya PO1,2, Meyer OW1,2, Ernst R1,2, Schietzel S1,2, Eberli F5, Staehelin HB6, Freystätter G1,2, Roas S1, Theiler R1,2, Egli A1,2, Wilson NM1,2.

1. Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland.

2. Centre on Aging and Mobility, University of Zurich and City Hospital Waid, Zurich, Switzerland.

3. Department of Biostatistics, School of Public Health, Harvard University, Boston, Massachusetts.

4. U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts.

5. Department of Cardiology, Triemli City Hospital, Zurich, Switzerland.

6. Department of Geriatrics, University of Basel, Basel, Switzerland.

Objectives

To determine whether statin use alters response of 25-hydroxyvitamin D (25(OH)D) level to vitamin D treatment.

Design

Pooled analysis.

Setting

Three double-blind randomized controlled trials that tested different doses of vitamin D.

Participants

Participants of three trials (N = 646; mean age 76.3 ± 8.4, 65% female).

Measurements

In all three trials, 25(OH)D status and statin use were assessed repeatedly over time (baseline, 6 and 12 months). Repeated-measures analysis was used to compare 25(OH)D response to vitamin D treatment at baseline and 6 and 12 months of statin users and nonusers, controlling for age, sex, body mass index, Charlson Comorbidity Index, vitamin D dose, trial, and season.

Results

At baseline, 17.5% were statin users, and 65% were vitamin D deficient (25(OH)D < 20 ng/mL). Baseline 25(OH)D levels did not differ significantly between groups at baseline (18.8 for statin users, 17.2 ng/mL for nonusers, P = .07), but according to the longitudinal analyses, the total increase over 12 months in 25(OH)D concentration was significantly lower in statin users (13.1 ng/L) than nonusers (15.9 ng/mL; 21.4% difference; P = .009).

Conclusion

Of persons aged 60 and older at high risk of vitamin D deficiency, statin users had a 21.4% smaller increase in 25(OH)D serum concentrations over time than nonusers, independent of vitamin D dose and other covariates.

J Am Geriatr Soc. 2017 Feb 27. doi: 10.1111/jgs.14784. [Epub ahead of print]

http://onlinelibrary.wiley.com/doi/10.1111/jgs.14784/abstract;jsessionid=5F6CEF2F9C66112DD3D63D73042DB09A.f02t02

Md. PhD. Patricia Chocano. Ex miembro del GII.