Valores de proteinuria y daño vascular en gestantes sanas, preeclámpticas y con hipertensión no proteinúrica, evaluados por ultrasonografía vascular
a Grupo de Investigación en Inmunología.
Facultad de Medicina. Universidad Nacional San Agustín de Arequipa. Arequipa.
Perú
b Instituto de Investigaciones Biomédicas.
Universidad Nacional Autónoma de México. México DF. México
c División de Cardiología y Cirugía de
Tórax. Hospital Nacional del Sur. CASE EsSalud. Arequipa. Perú
ABSTRACT
Objective
To compare the effectiveness of vascular ultrasonography and proteinuria in diagnosing systemic vascular damage.
Subjects and methods
Forty
healthy pregnant women, 35 with preeclampsia, and 35 with
non-proteinuric hypertension in the Yanahuara and Nacional del Sur
hospitals in Arequipa (Peru) underwent measurement of blood pressure,
proteinuria, and ultrasonographic studies in the humeral artery to
obtain their flow-mediated dilation (FMD). Comparisons between the three
groups were made using ANOVA or Kruskal-Wallis tests, depending on
whether the distribution was normal or non-normal, respectively. Values
of P<0.05 were considered statistically significant.
Results
Proteinuria
values were 0.05 g/24 h, 2.57 g/24 h and 0.21 g/24 h while FMD values
showed mean values of 0.66mm, 0.25mm, and 0.45mm for healthy pregnant
women, women with preeclampsia and women with non-proteinuric
hypertension, respectively. Comparison of FMD among groups showed
significant differences among the groups (P<.01). However,
proteinuria values in the group with non-proteinuric hypertension were
within the normal range (< 0.03 g/24 h). No relation was found
between FMD and proteinuria.
Conclusions
Ultrasonographic
evaluation of FMD detected vascular damage even in the group of
pregnant women with pregnancy-induced hypertension without proteinuria.
Progresos de Obstetricia y Ginecología 01/2009; 52(1). DOI:10.1016/S0304-5013(09)70139-6
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