Melanocitos
en vitíligo y melanoma: una lección
entre
autoinmunidad e inmunidad tumoral
Julio E Valdivia-Silva1, Claudia Ramírez1
1Chemokines
Biology Research Laboratory, Instituto de Investigaciones Biomédicas,
UNAM, México D.F., México.
ABSTRACT
Classically, vitiligo has been deined as a skin disease in which
melanocytes (MC) are eradicated from lesional epidermis by MC-reactive T
cells, as well as other non-immune and immune components, resulting in
disiguring loss of pigment. Moreover, the absence or damage on MC has
frequently been associated to a major risk to develop skin cancer
including melanoma. However, patients with vitiligo have also shown
'non-pigmented' MC in epidermis similar to individuals with albinism,
and these cells are apparently conferring resistance of developing
melanoma. These seemingly contradictory facts are further complicated
because, the MC antigens which are immunologically recognized are shared
for both diseases producing fairly different results. An analysis of
the similarities and differences between the autoimmunity observed in
vitiligo and the tumour immunity observed in melanoma might lead to a
better understanding of the MC' roles and the development of new
therapies for both diseases.
Dermatol
PerU 2013; vol 23 (3)
Md PhD Julio Valdivia Silva. Fundador del GII
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