Clinical Nutrition

Impaired nutritional status in geriatric trauma patients

F S Müller1,2,3, O W Meyer1,2,4, P Chocano-Bedoya1,2, S Schietzel1,2,4, M Gagesch1,2,4, G Freystaetter1,2,4, V Neuhaus4,5, H-P Simmen4,5, W Langhans3 and H A Bischoff-Ferrari1,2,4

1Department of Geriatrics and Aging Research, University Hospital Zurich, Zurich, Switzerland

2Centre on Aging and Mobility, University Hospital Zurich, Zurich, Switzerland

3Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

4Centre for Geriatric Traumatology, University Hospital Zurich, Zurich, Switzerland

5Department of Trauma Surgery, University Hospital Zurich, Zurich, Switzerland

Background/Objectives:

Malnutrition is an established risk factor for adverse clinical outcomes. Our aim was to assess nutritional status among geriatric trauma patients.

Subjects/Methods:

We enrolled 169 consecutive patients (greater than or equal to70 years) admitted to the Geriatric Traumatology Centre (University Hospital Zurich, Switzerland). On admission to acute care, nutritional status was assessed with the mini nutritional assessment (score<17=malnourished (M), less than or equal to23.5=at risk of malnutrition (ARM), >23.5=normal). At the same examination, we assessed mental (Geriatric Depression Scale; GDS) and cognitive function (Mini-Mental State Examination; MMSE), frailty status (Fried Scale), and number of comorbidities and medications. Further, discharge destination was documented. All analyses were adjusted for age and gender.

Results:

A total of 7.1% of patients were malnourished and 49.1% were ARM. Patients with reduced mental health (GDSgreater than or equal to5: 30.5 vs 11.5%; P=0.004), impaired cognitive function (MMSEless than or equal to26: 23.6±0.5 vs 26.0±0.6; P=0.004), prevalent frailty (32.5 vs 8%; P<0.001), more comorbidities (2.3±0.1 vs 1.3±0.2; P<0.0001) and medications (5.6±0.3 vs 3.4±0.4; P<0.0001) were more likely to have an impaired nutritional status (M+ARM). Further, M+ARM patients were twice as likely to be discharged to destinations different to home (odds ratio=2.08; confidence interval 1.07−4.05).

Conclusions:

In this consecutive sample of geriatric trauma patients, 56.2% had an M+ARM upon admission to acute care, which was associated with indicators of worse physical, mental and cognitive health and predicted a more than twofold greater odds of being discharged to a destination other than home.

European Journal of Clinical Nutrition (2017) 71, 602–606; doi:10.1038/ejcn.2017.25; published online 22 March 2017

https://www.nature.com/ejcn/journal/v71/n5/full/ejcn201725a.html

Md. PhD. Patricia Chocano. Ex miembro del GII. 

Microgravedad y Cáncer

Observation of development of breast cancer cell lines in real time by fluorescence microscopy under simulated microgravity

Lavan, David; Valdivia-Silva, Julio E.; Sanabria, Gabriela; Orihuela, Diego; Suarez, Juan; Quispe, Marco; Chuchon, Mariano; Martin, David; Maroto, Marcos; Egea, Javier

Abstract

This project consist in the implementation of a fluorescence microscope for the in real time monitoring of biological labeled samples by several fluorophores in microgravity conditions keeping the temperature, humidity, and (CO)2 controlled by an electronic platform. The system (fluorescence microscope and incubator) is integrated to a microgravity simulator machine which was presented on the "30th Annual American Society for Gravitation and Space Research Meeting" October 2014 in Pasadena, CA, USA. Currently, we have the microgravity machine biologically validated by genetic expression studies in pupal stage of Drosophila melanogaster. The fluorescence microscope has a platform designed to hold a culture flask, and a fluorescence camera (Leica DFC3000 G) connected to an optical system (Fluorescence Light source Leica EL6000, optic fiber, fiber adapter, and fluorescence filter) in order to take images in real time. The mechanical system of the fluorescence microsc ope is designed to allow the displacement of the fluorescence camera through a parallel plane to the culture flask's plane and also the movement of the platform through a perpendicular axis to the culture flask in order to focus the samples to the optical system. The mechanical system is propelled by four DC moto-reductors with encoder (A-max 26 Maxon motor, GP 32S screw and MR encoder) that generate displacements in the order of micrometers. The angular position control of the DC motoreductor's shaft of all the DC moto-reductors is done by PWM signals based on the interpretation of the signals provided by the encoders during the movement. The system is remotely operated by a graphic interface installed on a personal computer or any mobile device (smartphone, laptop or tablet) by using the internet. Acknowledgments: Grant of INNOVATE PERU (Formerly FINCYT)

Valdivia-Silva, Julio E : Fundador del GII

Aqui el link: http://adsabs.harvard.edu/abs/2016cosp...41E1128L