Endometrial leukocyte subpopulations associated with Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis genital tract infection.
Reighard SD1, Sweet RL, Vicetti Miguel C, Vicetti Miguel RD, Chivukula M, Krishnamurti U, Cherpes TL.
1Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
Abstract
OBJECTIVE:
The objective of the study was to characterize endometrial inflammation associated with common genital tract pathogens.
STUDY DESIGN:
The
design of the study was the immunohistochemical characterization of the
endometrial leukocyte subpopulations from 37 controls and 45 women
infected with Chlamydia trachomatis, Neisseria gonorrhoeae, or
Trichomonas vaginalis.
RESULTS:
Compared
with uninfected women, endocervical infection with C trachomatis, N
gonorrhoeae, or T vaginalis was associated with significant increases in
endometrial T cells, B cells, plasma cells, and polymorphonuclear
leukocytes. Even more substantial increases in T cell, B cell, and
plasma cell numbers were detected among women infected endocervically
and endometrially with C trachomatis.
CONCLUSION:
Because
lower genital tract C trachomatis, N gonorrhoeae, or T vaginalis
infections were associated with comparable increases in the same
endometrial leukocyte subpopulations, our results suggest the
underappreciated involvement of T vaginalis in upper genital tract
inflammatory processes. The more robust inflammatory infiltrate
associated with C trachomatis endometrial ascension may offer insight
into host inflammatory responses associated with pelvic inflammatory
disease development.
Copyright © 2011 Mosby, Inc. All rights reserved.
Am J Obstet Gynecol. 2011 Oct;205(4):324.e1-7. doi: 10.1016/j.ajog.2011.05.031. Epub 2011 May 20.
http://www.sciencedirect.com/science/article/pii/S0002937811006594
Md. Rodolfo Vicetti. Ex-miembro del GII.
