Dietary B vitamin intake and incident premenstrual syndrome.
Chocano-Bedoya PO1, Manson JE, Hankinson SE, Willett WC, Johnson SR, Chasan-Taber L, Ronnenberg AG, Bigelow C, Bertone-Johnson ER.
1Department of Public Health, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003-9304, USA.
Abstract
BACKGROUND:
Thiamine,
riboflavin, niacin, vitamin B-6, folate, and vitamin B-12 are required
to synthesize neurotransmitters that are potentially involved in the
pathophysiology of premenstrual syndrome (PMS).
OBJECTIVE:
The
objective was to evaluate whether B vitamin intake from food sources
and supplements is associated with the initial development of PMS.
DESIGN:
We
conducted a case-control study nested within the Nurses' Health Study
II cohort. Participants were free of PMS at baseline (1991). After 10 y
of follow up, 1057 women were confirmed as cases and 1968 were confirmed
as controls. Dietary information was collected in 1991, 1995, and 1999
by using food-frequency questionnaires.
RESULTS:
Intakes
of thiamine and riboflavin from food sources were each inversely
associated with incident PMS. For example, women in the highest quintile
of riboflavin intake 2-4 y before the diagnosis year had a 35% lower
risk of developing PMS than did those in the lowest quintile (relative
risk: 0.65; 95% CI: 0.45, 0.92; P for trend = 0.02). No significant
associations between incident PMS and dietary intakes of niacin, vitamin
B-6, folate, and vitamin B-12 were observed. Intake of B vitamins from
supplements was not associated with a lower risk of PMS.
CONCLUSIONS:
We
observed a significantly lower risk of PMS in women with high intakes
of thiamine and riboflavin from food sources only. Further research is
needed to evaluate the effects of B vitamins in the development of
premenstrual syndrome.
Am J Clin Nutr. 2011 May;93(5):1080-6. doi: 10.3945/ajcn.110.009530. Epub 2011 Feb 23.
http://ajcn.nutrition.org/content/93/5/1080.long
Md. PhD. Patricia Chocano. Ex miembro del GII.
