Effect of pro-inflammatory cytokine stimulation on human breast cancer: implications of chemokine receptor expression in cancer metastasis.
Valdivia-Silva JE1, Franco-Barraza J, Silva AL, Pont GD, Soldevila G, Meza I, García-Zepeda EA.
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, C.P. 04510 DF, Mexico.
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, C.P. 04510 DF, Mexico.
Abstract
Interactions
between tumour cells and microenvironments may affect their growth and
metastasis formation. In search for a better understanding of the role
of cellular mediators in the progression of cancer, we investigated the
effect of pro-inflammatory cytokines IL-1, IL-6, TNF-alpha and IFN-gamma
on the regulation of expression of chemokine receptors CXCR4, CXCR2,
CX3CR1, CCR9, and CCR5 in the human breast cancer cell line MCF-7. Our
results showed that IL-1 increased CXCR4 expression whereas TNF-alpha
increased CX3CR1, CCR9 and CCR5. Interestingly, this regulation was not
homogeneous, emphasizing the inherent heterogeneity in cancer that may
be responsive to specific inflammatory microenvironments.
Cancer Lett. 2009 Oct 8;283(2):176-85. doi: 10.1016/j.canlet.2009.03.040. Epub 2009 May 5.
http://www.ncbi.nlm.nih.gov/pubmed/19409696
